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Noboru Fukuda Selected Research

imidazole

4/2021Transcriptional Suppression of Diabetic Nephropathy with Novel Gene Silencer Pyrrole-Imidazole Polyamides Preventing USF1 Binding to the TGF-β1 Promoter.
6/2020Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells.
2/2020Contribution of TGF-β1 and Effects of Gene Silencer Pyrrole-Imidazole Polyamides Targeting TGF-β1 in Diabetic Nephropathy.
7/2015Pyrrole-imidazole polyamide-mediated silencing of KCNQ1OT1 expression induces cell death in Wilms' tumor cells.
1/2015Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.
10/2014Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth.
1/2014Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets an E-box motif.
1/2014Inhibition of human osteosarcoma cell migration and invasion by a gene silencer, pyrrole-imidazole polyamide, targeted at the human MMP9 NF-κB binding site.
11/2013Inhibition of MMP-9 using a pyrrole-imidazole polyamide reduces cell invasion in renal cell carcinoma.
7/2012Pyrrole-imidazole polyamide targeting transforming growth factor β1 ameliorates encapsulating peritoneal sclerosis.
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Noboru Fukuda Research Topics

Disease

16Hypertension (High Blood Pressure)
06/2021 - 07/2002
12Neoplasms (Cancer)
06/2021 - 01/2010
9Stroke (Strokes)
06/2021 - 11/2002
7Inflammation (Inflammations)
01/2020 - 12/2007
7Neointima
03/2009 - 01/2003
5Glomerulonephritis
01/2022 - 02/2007
5Cardiovascular Diseases (Cardiovascular Disease)
12/2016 - 11/2002
5Atherosclerosis
02/2010 - 01/2002
4Hyperaldosteronism (Conn Syndrome)
01/2021 - 01/2016
4Essential Hypertension
03/2017 - 02/2003
4Cicatrix (Scar)
01/2015 - 03/2010
4Myocardial Infarction
06/2010 - 11/2006
4Hyperplasia
03/2009 - 10/2006
4Vascular Diseases (Vascular Disease)
01/2006 - 01/2002
3Fibrosis (Cirrhosis)
09/2019 - 01/2011
3Neuroblastoma
06/2019 - 04/2017
3Insulin Resistance
01/2018 - 08/2002
3Proteinuria
05/2017 - 01/2007
3Osteosarcoma (Osteogenic Sarcoma)
01/2014 - 01/2010
3Ischemia
09/2010 - 02/2004
3Chronic Kidney Failure (Chronic Renal Failure)
02/2007 - 04/2004
2Diabetic Nephropathies (Diabetic Nephropathy)
04/2021 - 02/2020
2Renal Cell Carcinoma (Grawitz Tumor)
09/2017 - 11/2013
2Lupus Nephritis
05/2017 - 01/2012
2Burns
01/2015 - 03/2010
2Hypertrophic Cicatrix (Hypertrophic Scar)
01/2015 - 10/2011
2Body Weight (Weight, Body)
05/2014 - 01/2012
2Neoplasm Metastasis (Metastasis)
01/2014 - 03/2010
2Arteriosclerosis
02/2013 - 08/2002
2Peritoneal Fibrosis
07/2012 - 01/2007
2Nephrosclerosis
01/2011 - 03/2007
2Coronary Artery Disease (Coronary Atherosclerosis)
07/2009 - 03/2009
2Metabolic Syndrome (Dysmetabolic Syndrome X)
03/2009 - 08/2003
2Heart Failure
12/2007 - 04/2006
2Vascular System Injuries
11/2007 - 07/2004
2Infarction (Infarctions)
11/2006 - 01/2006
2Myocardial Ischemia (Ischemic Heart Diseases)
04/2006 - 01/2006
1Stress Urinary Incontinence
04/2022
1Snoring
03/2021
1Intellectual Disability (Idiocy)
12/2020
1Breast Neoplasms (Breast Cancer)
11/2020

Drug/Important Bio-Agent (IBA)

21Nylons (Nylon)IBA
04/2021 - 07/2008
12imidazoleIBA
04/2021 - 03/2010
12PyrrolesIBA
04/2021 - 03/2010
11Messenger RNA (mRNA)IBA
06/2021 - 01/2003
9DNA (Deoxyribonucleic Acid)IBA
12/2020 - 01/2003
8Transforming Growth Factors (Transforming Growth Factor)IBA
06/2020 - 11/2002
8Transforming Growth Factor beta1 (TGF beta 1)IBA
03/2010 - 11/2002
7SaltsIBA
01/2020 - 03/2007
6erucylphosphocholineIBA
12/2016 - 04/2006
6Catalytic RNA (Ribozymes)IBA
03/2007 - 01/2003
5Proteins (Proteins, Gene)FDA Link
05/2017 - 07/2008
5hammerhead ribozymeIBA
03/2007 - 01/2003
5RNA (Ribonucleic Acid)IBA
03/2007 - 01/2003
5platelet-derived growth factor AIBA
10/2006 - 01/2003
4AngiotensinsIBA
10/2013 - 02/2003
3EnzymesIBA
06/2021 - 07/2002
3ReninIBA
03/2021 - 10/2013
3AldosteroneIBA
01/2021 - 01/2016
3Insulin (Novolin)FDA Link
01/2018 - 08/2002
3Matrix Metalloproteinase 9 (Gelatinase B)IBA
01/2014 - 03/2010
3Angiotensin IIIBA
03/2011 - 01/2002
3CytokinesIBA
02/2010 - 07/2002
3Transforming Growth Factor beta (TGF-beta)IBA
11/2009 - 11/2002
2ErbB Receptors (EGF Receptor)IBA
06/2021 - 09/2017
2Streptozocin (Streptozotocin)FDA Link
04/2021 - 02/2020
2Pharmaceutical PreparationsIBA
06/2020 - 08/2005
2Complement System Proteins (Complement)IBA
01/2020 - 01/2007
2Complement C3 (C3 Complement)IBA
01/2020 - 12/2018
2Biological ProductsIBA
06/2019 - 02/2010
2CalciumIBA
09/2017 - 12/2007
2Butylated Hydroxyanisole (BHA)IBA
04/2017 - 01/2016
2Transcription Factors (Transcription Factor)IBA
04/2017 - 01/2014
2Doxorubicin (Adriamycin)FDA LinkGeneric
04/2017 - 04/2015
2Adrenocorticotropic Hormone (ACTH)FDA Link
03/2017 - 01/2016
2Interleukin-6 (Interleukin 6)IBA
04/2015 - 06/2009
2Losartan (Cozaar)FDA LinkGeneric
05/2014 - 11/2007
2Trichlormethiazide (Naqua)FDA Link
05/2014 - 11/2007
2LipidsIBA
05/2014 - 03/2009
2Matrix Metalloproteinases (MMPs)IBA
01/2014 - 03/2010
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2011 - 07/2004
2Valsartan (Vals)FDA Link
01/2011 - 09/2010
2Granulocyte Colony-Stimulating Factor (G-CSF)IBA
02/2010 - 11/2006
2oxidized low density lipoproteinIBA
07/2009 - 03/2009
2LeptinIBA
08/2003 - 02/2003
1Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
01/2022
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2022
1Phytanic AcidIBA
06/2021
1Fatty Acids (Saturated Fatty Acids)IBA
06/2021
1Acyl-CoA OxidaseIBA
06/2021
1A-Form DNA (A-DNA)IBA
06/2021
1AmidophosphoribosyltransferaseIBA
12/2020

Therapy/Procedure

8Therapeutics
04/2022 - 01/2003
5Renal Dialysis (Hemodialysis)
12/2007 - 04/2004
4Transplantation
12/2016 - 02/2004
2Cell- and Tissue-Based Therapy (Cell Therapy)
01/2022 - 01/2006
2Peritoneal Dialysis
07/2012 - 01/2007
2Drug-Eluting Stents
03/2009 - 10/2006
2Stents
10/2006 - 01/2006
1Intravenous Administration
04/2021